Nitro-tyrosine as promoter of free radical damage in a DNA model system.

  • W A Prütz
  • Published 1986 in Free radical research communications

Abstract

Nitro-tyrosine considerably promotes the degradation of DNA, when incubated with Cu2+ and ascorbate in oxygenated aqueous solution. This deleterious process requires oxygen and can be inhibited with catalase, indicating that H2O2 is involved, via the reduction of oxygen. Menadione and 2,4,6-trinitrobenzenesulfonate, known to catalyze particularly fast such… (More)

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