Nitro-L-arginine methyl ester: a potential protector against gentamicin ototoxicity.

  title={Nitro-L-arginine methyl ester: a potential protector against gentamicin ototoxicity.},
  author={Leif Nordang and Matti Anniko},
  journal={Acta oto-laryngologica},
  volume={125 10},
The nitric oxide (NO) inhibitor nitro-L-arginine methyl ester (L-NAME) may act as an otoprotectant against high-frequency hearing loss caused by gentamicin, but further studies are needed to confirm this.Aminoglycoside antibiotics are still widely used by virtue of their efficacy and low cost. Their ototoxicity is a serious health problem and, as their ototoxic mechanism involves the production of NO, we need to assess the use of NO inhibitors for the prevention of aminoglycoside-induced… CONTINUE READING


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