Nitro-L-arginine attenuates hypercapnic cerebrovasodilation without affecting cerebral metabolism.

@article{Iadecola1994NitroLarginineAH,
  title={Nitro-L-arginine attenuates hypercapnic cerebrovasodilation without affecting cerebral metabolism.},
  author={C Iadecola and Xiaobin Xu},
  journal={The American journal of physiology},
  year={1994},
  volume={266 2 Pt 2},
  pages={R518-25}
}
We have previously demonstrated that topical cortical application of nitro-L-arginine (L-NA), a potent inhibitor of nitric oxide (NO) synthesis, attenuates resting cerebral blood flow (CBF) and the cerebrovasodilation elicited by hypercapnia. In this study, we sought to determine whether these cerebrovascular effects of L-NA are secondary to a depression in… CONTINUE READING