Nitrite regulates hypoxic vasodilation via myoglobin-dependent nitric oxide generation.

Abstract

BACKGROUND Hypoxic vasodilation is a physiological response to low oxygen tension that increases blood supply to match metabolic demands. Although this response has been characterized for >100 years, the underlying hypoxic sensing and effector signaling mechanisms remain uncertain. We have shown that deoxygenated myoglobin in the heart can reduce nitrite to… (More)
DOI: 10.1161/CIRCULATIONAHA.111.087155

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