Nitrite is an alternative source of NO in vivo.

@article{Tsuchiya2005NitriteIA,
  title={Nitrite is an alternative source of NO in vivo.},
  author={Koichiro Tsuchiya and Yasuhisa Kanematsu and Munenori Yoshizumi and Hachiro Ohnishi and Kazuyoshi Kirima and Yuki Izawa and Michiyo Shikishima and Tatsuhiro Ishida and Shuji Kondo and Shoji Kagami and Yoshiharu Takiguchi and Toshiaki Tamaki},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2005},
  volume={288 5},
  pages={
          H2163-70
        }
}
In this study, we investigated whether orally administered nitrite is changed to NO and whether nitrite attenuates hypertension in a dose-dependent manner. We utilized a stable isotope of [15N]nitrite (15NO2-) as a source of nitrite to distinguish between endogenous nitrite and that exogenously administered and measured hemoglobin (Hb)-NO as an index of circulating NO in whole blood using electron paramagnetic resonance (EPR) spectroscopy. When 1 mg/kg Na15NO2 was orally administered to rats… CONTINUE READING

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