Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues.

@article{Bryan2005NitriteIA,
  title={Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues.},
  author={Nathan S. Bryan and Bernadette O. Fernandez and Selena M Bauer and Mar{\'i}a Francisca Garc{\'i}a-Saura and Alexandra B. Milsom and Tienush Rassaf and Ronald E. Maloney and A. C. Bharti and Juan L. Estrada Rodriguez and Martin Feelisch},
  journal={Nature chemical biology},
  year={2005},
  volume={1 5},
  pages={290-7}
}
Mammalian tissues produce nitric oxide (NO) to modify proteins at heme and sulfhydryl sites, thereby regulating vital cell functions. The majority of NO produced is widely assumed to be neutralized into supposedly inert oxidation products including nitrite (NO2(-)). Here we show that nitrite, also ubiquitous in dietary sources, is remarkably efficient at modifying the same protein sites, and that physiological nitrite concentrations account for the basal levels of these modifications in vivo… CONTINUE READING