Nitrite is a positive modulator of the Frank-Starling response in the vertebrate heart.
@article{Angelone2012NitriteIA, title={Nitrite is a positive modulator of the Frank-Starling response in the vertebrate heart.}, author={Tommaso Angelone and Alfonsina Gattuso and Sandra Imbrogno and Rosa Mazza and Bruno Tota}, journal={American journal of physiology. Regulatory, integrative and comparative physiology}, year={2012}, volume={302 11}, pages={ R1271-81 }, url={https://api.semanticscholar.org/CorpusID:16987587} }
The results suggest that nitrite acts as a physiological source of NO, modulating through different species-specific mechanisms, the stretch-induced intrinsic regulation of the vertebrate heart.
32 Citations
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It is proposed that the in vitro working heart of the eel Anguilla anguilla represents an important evolutionary step for the stretch-induced intrinsic regulation of the vertebrate heart, providing, at the same time, a stimulus for mammalian-oriented studies.
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HNO/NO− has positive inotropic and lusitropic action, which unlike NO/nitrates is independent and additive to β-adrenergic stimulation and stimulates CGRP release, which suggests potential of HNO/ NO− donors for the treatment of heart failure.
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The fatty acid oxidation is necessary for an adequate contractile response of the isolated heart to increased pre-load or flow, whereas the inotropic response to adrenergic beta-receptor stimulation is insensitive to changes in substrate availability.
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