Nitrite-induced adrenal effects in rats and the consequences for the no-observed-effect level.

@article{Til1997NitriteinducedAE,
  title={Nitrite-induced adrenal effects in rats and the consequences for the no-observed-effect level.},
  author={H. P. Til and Christine F Kuper and Hein E. Falke},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={1997},
  volume={35 3-4},
  pages={349-55}
}
In a previous subchronic oral toxicity study with potassium nitrite, hypertrophy of the adrenal zona glomerulosa was observed for all nitrite levels examined including the lowest level of 100 mg/litre. This present study was carried out, therefore, to establish a no-observed-effect level (NOEL) for nitrite. Groups of 10 male and 10 female 6-wk-old Wistar rats received KNO2 at levels of 12.5, 25, 50, 100 or 3000 mg/litre or NaNO2 at levels of 81 or 2432 mg/litre in the drinking water for 13 wk… CONTINUE READING