Nitrite-derived nitric oxide formation following ischemia-reperfusion injury in kidney.

@article{Okamoto2005NitritederivedNO,
  title={Nitrite-derived nitric oxide formation following ischemia-reperfusion injury in kidney.},
  author={Masumi Okamoto and Koichiro Tsuchiya and Yasuhisa Kanematsu and Yuki Izawa and Masanori Yoshizumi and Susumu Kagawa and Toshiaki Tamaki},
  journal={American journal of physiology. Renal physiology},
  year={2005},
  volume={288 1},
  pages={F182-7}
}
Nitric oxide (NO) is synthesized from l-arginine by nitric oxide synthase (NOS), and nitrite and nitrate are believed to be waste forms of NO. We previously reported an enzyme-independent pathway of NO generation from nitrite in acidic conditions. In this study, we show nitrite-derived NO formation in renal ischemia-reperfusion injury using electron paramagnetic resonance (EPR) spectroscopy. In this experiment, we utilized a stable isotope of [(15)N]nitrite as a source of nitrite to distinguish… CONTINUE READING

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