Nitrite-derived nitric oxide: a possible mediator of 'acidic-metabolic' vasodilation.

  title={Nitrite-derived nitric oxide: a possible mediator of 'acidic-metabolic' vasodilation.},
  author={A. Yu. Modin and H{\aa}kan Bj{\"o}rne and Max Herulf and Kjell Alving and Eddie Weitzberg and Jon O N Lundberg},
  journal={Acta physiologica Scandinavica},
  volume={171 1},
The fundamental, yet poorly understood, physiological mechanism known as 'acidic-metabolic' vasodilation, contributes to local blood flow regulation during hypoxia/ischaemia and increased metabolic activity. The vasodilator nitric oxide (NO) has been suggested to be involved in this event. Besides enzymatic production by NO synthases, a novel mechanism for generation of this gas in vivo was recently described. This involves non-enzymatic reduction of inorganic nitrite to NO, a reaction that… CONTINUE READING


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