Nitrite and malondialdehyde content in cerebrospinal fluid of patients with Parkinson's disease.

@article{Shukla2006NitriteAM,
  title={Nitrite and malondialdehyde content in cerebrospinal fluid of patients with Parkinson's disease.},
  author={Rakesh Kumar Shukla and Mira Rajani and Nupur Srivastava and Manoj Kumar Barthwal and Madhu Dikshit},
  journal={The International journal of neuroscience},
  year={2006},
  volume={116 12},
  pages={1391-402}
}
Evidence from clinical and experimental studies supports the hypothesis of free radical-mediated damage of dopaminergic neurons in the pathology of Parkin's disease (PD). The present study was undertaken to evaluate the role of nitric oxide and oxidative stress in PD. Estimation of the stable metabolites of nitric oxide (NO, nitrite, nitrate) and malondialdehyde (MDA), an acceptable marker of lipid peroxidation, can provide indirect evidence of involvement of free radicals. Nitrite and… CONTINUE READING
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