Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells

@article{Stuehr1989NitricOA,
  title={Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells},
  author={Dennis J. Stuehr and Carl Nathan},
  journal={The Journal of Experimental Medicine},
  year={1989},
  volume={169},
  pages={1543 - 1555}
}
A metabolic pathway of activated macrophages (M phi) involving oxidation of the guanido nitrogens of L-arginine is required for inhibition of growth and respiration of some target cells. The goal of this study was to identify the M phi metabolite(s) that induce these injuries. The stable products of the L-arginine pathway, NO2- and NO3-, were incapable of causing cytostasis under coculture conditions. However, NO2- became cytostatic upon mild acidification, which favors its transformation into… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 36 references

Macro - phage oxidation or L - arginine to nitrite and nitrate : nitric oxide is an intermediate

  • J. B. Hibbs, Z. Vavrin, E. M. Rachlin
  • 1988

Release ofreactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages : comparison of activating cytokines and evidence for independent production

  • D. J. Stuehr
  • J . Immunol .
  • 1988

macrophages by BCG infection, lymphokines, or interferon-y

  • R. Iyengar, D. J . Stuehr, M. A . Marletta
  • J. Immunol
  • 1987