Nitric oxide upregulation of caspase-8 mRNA expression in lung endothelial cells: role of JAK2/STAT-1 signaling

@article{Li2007NitricOU,
  title={Nitric oxide upregulation of caspase-8 mRNA expression in lung endothelial cells: role of JAK2/STAT-1 signaling},
  author={Liuzhe Li and Jianliang Zhang and Bilian Jin and Edward R. Block and Jawaharlal M. Patel},
  journal={Molecular and Cellular Biochemistry},
  year={2007},
  volume={305},
  pages={71-77}
}
We recently reported that nitric oxide (NO) modulates expression of multiple genes associated with apoptotic pathways, including expression of caspase-8. The objective of the present study is to determine whether the NO-induced expression of the caspase-8 gene is regulated via signal transducers and activators of transcription-1 (STAT-1) signaling. The confluent monolayers of pulmonary artery endothelial cells (PAEC) were incubated with or without (control) 1 mM NOC-18, a NO donor, at 37°C for… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 27 references

Interferon gamma is required for activation-induced death of T lymphocytes

Y Refaeli, L Van Parijs, SI Alexander
J Exp Med • 2002
View 1 Excerpt