Nitric oxide trapping of the tyrosyl radical of prostaglandin H synthase-2 leads to tyrosine iminoxyl radical and nitrotyrosine formation.

@article{Gunther1997NitricOT,
  title={Nitric oxide trapping of the tyrosyl radical of prostaglandin H synthase-2 leads to tyrosine iminoxyl radical and nitrotyrosine formation.},
  author={Michael R. Gunther and Linda C. Hsi and Johanna Curtis and James K. Gierse and Lawrence J Marnett and Thomas E. Eling and Ronald Paul Mason},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 27},
  pages={17086-90}
}
The determination of protein nitrotyrosine content has become a frequently used technique for the detection of oxidative tissue damage. Protein nitration has been suggested to be a final product of the production of highly reactive nitrogen oxide intermediates (e. g. peroxynitrite) formed in reactions between nitric oxide (NO.) and oxygen-derived species such as superoxide. The enzyme prostaglandin H synthase-2 (PHS-2) forms one or more tyrosyl radicals during its enzymatic catalysis of… CONTINUE READING

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