Nitric oxide transport on sickle cell hemoglobin: where does it bind?

@article{Gladwin2001NitricOT,
  title={Nitric oxide transport on sickle cell hemoglobin: where does it bind?},
  author={Mark T Gladwin and Frederick P Ognibene and James H. Shelhamer and Margaret E Pease-Fye and Constance Tom Noguchi and Griffin P. Rodgers and Alan N Schechter},
  journal={Free radical research},
  year={2001},
  volume={35 2},
  pages={175-80}
}
We have recently reported that nitric oxide inhalation in individuals with sickle cell anemia increases the level of NO bound to hemoglobin, with the development of an arterial-venous gradient, suggesting delivery to the tissues. A recent model suggests that nitric oxide, in addition to its well-known reaction with heme groups, reacts with the beta-globin… CONTINUE READING