Nitric oxide synthesis and isoprostane production in subjects with type 1 diabetes and normal urinary albumin excretion.

@article{OByrne2000NitricOS,
  title={Nitric oxide synthesis and isoprostane production in subjects with type 1 diabetes and normal urinary albumin excretion.},
  author={Sharon O'Byrne and Pablo Forte and L. Jackson Roberts and Jason D. Morrow and Atholl Johnston and Erik E Angg{\aa}rd and R David Leslie and Nigel Benjamin},
  journal={Diabetes},
  year={2000},
  volume={49 5},
  pages={857-62}
}
The role of nitric oxide (NO) and free radicals in the development of microvascular disease in type 1 diabetes remains unclear. We have measured NO and isoprostane (a stable marker of in vivo lipid peroxidation) production in 13 type 1 diabetic subjects with normal urinary albumin excretion and 13 healthy volunteers. Whole-body NO synthesis was quantified by measuring the urinary excretion of 15N-nitrate after the intravenous administration of L-[15N]2-arginine. The urinary excretion of the… CONTINUE READING

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