Nitric oxide synthase variants and disease-free survival among treated and untreated breast cancer patients in a Southwest Oncology Group clinical trial.

@article{Choi2009NitricOS,
  title={Nitric oxide synthase variants and disease-free survival among treated and untreated breast cancer patients in a Southwest Oncology Group clinical trial.},
  author={Ji-Yeob Choi and William Eric Barlow and Kathy S. Albain and Chi-chen Hong and Javier G Blanco and Robert B. Livingston and Warren Davis and James Michael Rae and I J Yeh and Laura Hutchins and Peter Marcus Ravdin and Silvana Martino and Alan P. Lyss and Charles Osborne and Martin D. Abeloff and Daniel F. Hayes and Christine B. Ambrosone},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2009},
  volume={15 16},
  pages={5258-66}
}
PURPOSE Numerous chemotherapeutic agents are cytotoxic through generation of reactive species, and variability in genes related to oxidative stress may influence disease-free survival (DFS). We examined relationships between DFS and variants in NOS3, as well as NQO1, NQO2, and CBR3, among treated and untreated breast cancer patients in a Southwest Oncology Group clinical trial (S8897). EXPERIMENTAL DESIGN In the parent trial, women were assigned according to prognostic features; the high-risk… CONTINUE READING

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