Nitric oxide synthase reduces nitrite to NO under anoxia

Abstract

Cultured bEND.3 endothelial cells show a marked increase in NO production when subjected to anoxia, even though the normal arginine pathway of NO formation is blocked due to absence of oxygen. The rate of anoxic NO production exceeds basal unstimulated NO synthesis in normoxic cells. The anoxic release of NO is mediated by endothelial nitric oxide synthase… (More)
DOI: 10.1007/s00018-006-6374-2

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