Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis.

@article{Ziche1997NitricOS,
  title={Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis.},
  author={Marina Ziche and Lucia Morbidelli and Rangana Choudhuri and H T Zhang and Sandra Donnini and Harris J. Granger and Roy Bicknell},
  journal={The Journal of clinical investigation},
  year={1997},
  volume={99 11},
  pages={2625-34}
}
Systemic administration of the nitric oxide (NO) synthase inhibitor Nomega-nitro--arginine methyl ester (L-NAME) to rabbits bearing a corneal implant blocked vascular endothelial growth factor (VEGF), but not basic fibroblast growth factor (bFGF)-induced angiogenesis. L-NAME completely blocked angiogenesis induced by VEGF-transfected MCF-7 breast carcinoma cells and the cells remained dormant in the cornea. Postcapillary endothelial cell migration and growth induced by VEGF were blocked by both… CONTINUE READING
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