Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels.

@article{Calabrese2002NitricOS,
  title={Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels.},
  author={Vittorio Calabrese and Giovanni Scapagnini and Agrippino Ravagna and Rita Bella and Roberta Foresti and Timothy E. Bates and Anna-Maria Giuffrida Stella and Giovanni Pennisi},
  journal={Journal of neuroscience research},
  year={2002},
  volume={70 4},
  pages={
          580-7
        }
}
Nitric oxide (NO) is hypothesized to play a role in the immunopathogenesis of multiple sclerosis (MS). Increased levels of NO metabolites have been found in patients with MS. Peroxynitrite, generated by the reaction of NO with superoxide at sites of inflammation, is a strong oxidant capable of damaging tissues and cells. Inducible NO synthase (iNOS) is up-regulated in the CNS of animals with experimental allergic encephalomyelitis (EAE) and in patients with MS. In this study, Western blots of… CONTINUE READING

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