Nitric oxide synthase is expressed in human macrophages during foreign body inflammation.

@article{Moilanen1997NitricOS,
  title={Nitric oxide synthase is expressed in human macrophages during foreign body inflammation.},
  author={Eveliina Moilanen and Teemu P S Moilanen and Roccou Knowles and I. P. Charles and Yoshinori Kadoya and Najat M. Al-Saffar and PeterA. Revell and Salvador Moncada},
  journal={The American journal of pathology},
  year={1997},
  volume={150 3},
  pages={
          881-7
        }
}
Although nitric oxide (NO) is a well documented effector molecule in rodent macrophages, its significance in human mononuclear phagocytic cells has been controversial. The foreign body inflammatory reaction around loosened joint replacement implants leads to formation of an osteolytic granulomatous pseudo-synovial membrane rich in activated macrophages. We studied 13 specimens of interface membrane tissue collected from revision surgery of aseptically loosened hip and knee prostheses for the… CONTINUE READING

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