Nitric oxide synthase inhibitors protect against rotenone-induced, oxidative stress mediated parkinsonism in rats.

@article{Madathil2013NitricOS,
  title={Nitric oxide synthase inhibitors protect against rotenone-induced, oxidative stress mediated parkinsonism in rats.},
  author={K S Madathil and Saravanan S. Karuppagounder and Reena Haobam and Merina Varghese and Usha Rajamma and Kochupurackal Parameswarannayar Mohanakumar},
  journal={Neurochemistry international},
  year={2013},
  volume={62 5},
  pages={674-83}
}
Rotenone is known to cause progressive dopaminergic neuronal loss in rodents, but it remains unclear how this mitochondrial complex-I inhibitor mediates neurodegeneration specific to substantia nigra pars compacta (SNpc). One of the proposed mechanisms is increased free radical generation owing to mitochondrial electron transport chain dysfunction following… CONTINUE READING