Nitric oxide synthase inhibitors l-NAME and 7-nitroindazole protect rat hippocampus against kainate-induced excitotoxicity

@article{Jones1998NitricOS,
  title={Nitric oxide synthase inhibitors l-NAME and 7-nitroindazole protect rat hippocampus against kainate-induced excitotoxicity},
  author={Patricia A. Jones and Robert A. Smith and Trevor W Stone},
  journal={Neuroscience Letters},
  year={1998},
  volume={249},
  pages={75-78}
}
The role of nitric oxide in cerebral insults remains controversial. While numerous studies have used models of ischaemia and hypoxia, few have examined nitric oxide in the kainate model of excitotoxicity. Kainate (10 mg/kg) was administered to rats via the intraperitoneal (i.p.) route to induce submaximal damage to the CA1, CA2 and CA3a regions of the hippocampus after 7 days. Systemic injections of the nitric oxide synthase (NOS) inhibitors N(G)-nitro-L-arginine methyl ester (L-NAME) and 7… CONTINUE READING

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