Nitric oxide synthase inhibition versus norepinephrine for the treatment of hyperdynamic sepsis in sheep.


OBJECTIVES To investigate the effects of Nomega-mono-methyl-L-arginine (L-NMMA), an inhibitor of nitric oxide synthesis, on hemodynamics, oxygen transport, and regional blood flow in an ovine model of hyperdynamic sepsis and to compare these effects with the responses to norepinephrine. DESIGN Prospective, nonrandomized, controlled experimental study with… (More)


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