Nitric oxide synthase inhibition is detrimental to cardiac function and promotes bronchospasm in anaphylaxis in rabbits.

@article{Mitsuhata1995NitricOS,
  title={Nitric oxide synthase inhibition is detrimental to cardiac function and promotes bronchospasm in anaphylaxis in rabbits.},
  author={Hiromasa Mitsuhata and Jin Saitoh and Naoki Hasome and Haruhiko Takeuchi and Yutaka Horiguchi and Reiju Shimizu},
  journal={Shock},
  year={1995},
  volume={4 2},
  pages={143-8}
}
We studied the effects of a nitric oxide synthase (NOS) inhibitor, N omega-nitro-L-arginine-methyl ester (L-NAME), on cardiac depression and bronchospasm provoked by systemic anaphylaxis in vivo in rabbits. Animals pretreated with L-NAME showed lower survival rates than control animals pretreated with normal saline. The survival rate in L-NAME-pretreated animals was increased by the administration of L-arginine after initiation of anaphylaxis. Cardiac output fell significantly in animals… CONTINUE READING

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