Nitric oxide synthase inhibition decreases output of hepatic insulin sensitizing substance (HISS), which is reversed by SIN-1 but not by nitroprusside.

@article{Guarino2001NitricOS,
  title={Nitric oxide synthase inhibition decreases output of hepatic insulin sensitizing substance (HISS), which is reversed by SIN-1 but not by nitroprusside.},
  author={Maria Pedro Sucena Guarino and Nina Cruz Correia and Joao Canelas Raposo and M Paula Macedo},
  journal={Proceedings of the Western Pharmacology Society},
  year={2001},
  volume={44},
  pages={
          25-6
        }
}
Insulin sensitivity is dependent on a HISS (hepatic insulin sensitizing substance)-dependent component and on a HISS-independent component [1]. HISS sensitizes skeletal muscle to insulin. Its release is dependent on the activation of hepatic muscarinic receptors. Moreover, nitric oxide (NO) produced in the liver is a key regulator of HISS release [2]. We studied the ability of different NO donors to reverse HISS-dependent insulin resistance. Two NO donors with distinct chemistries were used… CONTINUE READING

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