Nitric oxide synthase inhibition blocks phencyclidine-induced behavioural effects on prepulse inhibition and locomotor activity in the rat

@article{Johansson1997NitricOS,
  title={Nitric oxide synthase inhibition blocks phencyclidine-induced behavioural effects on prepulse inhibition and locomotor activity in the rat},
  author={Christina Johansson and David M. Jackson and Lennart Svensson},
  journal={Psychopharmacology},
  year={1997},
  volume={131},
  pages={167-173}
}
The ability of the nitric oxide synthase inhibitor, N G-nitro-L-arginine methyl ester (L-NAME), to block the behavioural effects of the potent psychotomimetic, phencyclidine, was tested in rats using two different behavioural models. L-NAME was found to block both phencyclidine-induced disruption of prepulse inhibition of acoustic startle and phencyclidine-induced stimulation of locomotor activity. A selective action of L-NAME on the effects of phencyclidine was indicated, since L-NAME did not… CONTINUE READING

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Concomitant measurement of prepulse inhibition and dopamine release in rats

  • L Svensson, J Zhang, JA Engel
  • 7th International Conference on in vivo Methods…
  • 1996
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