Nitric oxide synthase-independent generation of nitric oxide in muscle ischemia--reperfusion injury.

@article{Lepore2000NitricOS,
  title={Nitric oxide synthase-independent generation of nitric oxide in muscle ischemia--reperfusion injury.},
  author={Diana A. Lepore},
  journal={Nitric oxide : biology and chemistry},
  year={2000},
  volume={4 6},
  pages={
          541-5
        }
}
Nitric oxide (NO) is an important molecule in many physiological or pathophysiological processes including ischemia--reperfusion injury. The enzymatic nitric oxide synthase (NOS)-dependent pathway was universally accepted as the source of NO in ischemia-reperfusion injury. However, generation of NO that is independent of NOS has also been identified in ischemia--reperfusion injury to both cardiac and skeletal muscle. This review summarizes the evidence for the generation NOS-independent NO in… CONTINUE READING

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