Nitric oxide synthase generates nitric oxide locally to regulate compartmentalized protein S-nitrosylation and protein trafficking.

@article{Iwakiri2006NitricOS,
  title={Nitric oxide synthase generates nitric oxide locally to regulate compartmentalized protein S-nitrosylation and protein trafficking.},
  author={Yasuko Iwakiri and Ayano Satoh and Suvro Chatterjee and Derek Toomre and Cecile M Chalouni and David Fulton and Roberto J. Groszmann and Vijay H Shah and William C Sessa},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 52},
  pages={19777-82}
}
Nitric oxide (NO) is a highly diffusible and short-lived physiological messenger. Despite its diffusible nature, NO modifies thiol groups of specific cysteine residues in target proteins and alters protein function via S-nitrosylation. Although intracellular S-nitrosylation is a specific posttranslational modification, the defined localization of an NO source (nitric oxide synthase, NOS) with protein S-nitrosylation has never been directly demonstrated. Endothelial NOS (eNOS) is localized… CONTINUE READING

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