Nitric oxide synthase gene polymorphisms and diabetic nephropathy


Aims/hypothesis. Susceptibility to diabetic nephropathy in subjects with Type 1 diabetes is mainly genetically determined. Excess cardiovascular risk associated with diabetes is overwhelmingly concentrated in patients with nephropathy. Endothelial dysfunction is a feature of cardiovascular disease, hypertension, dyslipidaemia and smoking, all of which are… (More)
DOI: 10.1007/s00125-003-1046-3


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