Nitric oxide synthase expression in the course of lead-induced hypertension.

@article{Vaziri1999NitricOS,
  title={Nitric oxide synthase expression in the course of lead-induced hypertension.},
  author={Nosratola D. Vaziri and Y Ding and Zhenmin Ni},
  journal={Hypertension},
  year={1999},
  volume={34 4 Pt 1},
  pages={558-62}
}
We recently showed elevated reactive oxygen species (ROS), reduced urinary excretion of NO metabolites (NOx), and increased NO sequestration as nitrotyrosine in various tissues in rats with lead-induced hypertension. This study was designed to discern whether the reduction in urinary NOx in lead-induced hypertension is, in part, due to depressed NO synthase (NOS) expression. Male Sprague-Dawley rats were randomly assigned to a lead-treated group (given lead acetate, 100 ppm, in drinking water… CONTINUE READING
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