Nitric oxide synthase expression in endothelial cells exposed to mechanical forces.

@article{Ziegler1998NitricOS,
  title={Nitric oxide synthase expression in endothelial cells exposed to mechanical forces.},
  author={Tom Ziegler and Paolo Silacci and V J Harrison and Daniel Hayoz},
  journal={Hypertension},
  year={1998},
  volume={32 2},
  pages={351-5}
}
Nitric oxide (NO) has been demonstrated to play a central role in vascular biology and pathobiology. The expression of endothelial NO synthase (eNOS) is regulated in part by blood flow-induced mechanical factors. The purpose of this study was to evaluate how the expression of eNOS mRNA correlates with the activation of its promoter in both arterial and venous endothelial cells (ECs) exposed to mechanical forces, ie, shear stress and cyclic circumferential stretch. Bovine aortic ECs (BAECs) and… CONTINUE READING