Nitric oxide synthase deficiency and the pathophysiology of muscular dystrophy.

@article{Tidball2014NitricOS,
  title={Nitric oxide synthase deficiency and the pathophysiology of muscular dystrophy.},
  author={James G. Tidball and Michelle Wehling-Henricks},
  journal={The Journal of physiology},
  year={2014},
  volume={592 21},
  pages={4627-38}
}
The secondary loss of neuronal nitric oxide synthase (nNOS) that occurs in dystrophic muscle is the basis of numerous, complex and interacting features of the dystrophic pathology that affect not only muscle itself, but also influence the interaction of muscle with other tissues. Many mechanisms through which nNOS deficiency contributes to misregulation of muscle development, blood flow, fatigue, inflammation and fibrosis in dystrophic muscle have been identified, suggesting that normalization… CONTINUE READING

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