Nitric oxide synthase and renin–angiotensin gene expression and NOS function in the postnatal renal resistance vasculature

@article{Ratliff2008NitricOS,
  title={Nitric oxide synthase and renin–angiotensin gene expression and NOS function in the postnatal renal resistance vasculature},
  author={Brian B. Ratliff and Justin Rodebaugh and Miroslav Sekulic and Ke-Wen Dong and Michael J. Solhaug},
  journal={Pediatric Nephrology},
  year={2008},
  volume={24},
  pages={355-365}
}
Nitric oxide (NO), produced by nitric oxide synthase (NOS), critically counteracts angiotensin-II-enhanced vascular resistance in the immature kidney, perhaps due to the developmental regulation of NOS expression and function in the postnatal preglomerular resistance vessels (PRV). Our experiments measured the messenger ribonucleic acid (mRNA) gene expression of neuronal NOS (nNOS), endothelial NOS (eNOS), and components of the renin–angiotensin system (renin, AT1 and AT2 receptors), by real… CONTINUE READING