Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues.

@article{Dawson1991NitricOS,
  title={Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues.},
  author={Ted M Dawson and David S. Bredt and Majid Fotuhi and Paul M. Hwang and Solomon H Snyder},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 17},
  pages={7797-801}
}
NADPH diaphorase staining neurons, uniquely resistant to toxic insults and neurodegenerative disorders, have been colocalized with neurons in the brain and peripheral tissue containing nitric oxide synthase (EC 1.14.23.-), which generates nitric oxide (NO), a recently identified neuronal messenger molecule. In the corpus striatum and cerebral cortex, NO synthase immunoreactivity and NADPH diaphorase staining are colocalized in medium to large aspiny neurons. These same neurons colocalize with… CONTINUE READING
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