Nitric oxide synthase and cyclic GMP signaling in cardiac myocytes: from contractility to remodeling.

@article{Hammond2012NitricOS,
  title={Nitric oxide synthase and cyclic GMP signaling in cardiac myocytes: from contractility to remodeling.},
  author={Joanna Hammond and Jean-Luc Balligand},
  journal={Journal of molecular and cellular cardiology},
  year={2012},
  volume={52 2},
  pages={330-40}
}
Cyclic guanosine 3'5'monophosphate (cGMP) is the common downstream second messenger of natriuretic peptides and nitric oxide. In cardiac myocytes, the physiological effects of cGMP are exerted through the activation of protein kinase G (PKG) signaling, and the activation and/or inhibition of phosphodiesterases (PDEs), providing an integration point between cAMP and cGMP signals. Specificity of cGMP signals is achieved through compartmentalization of cGMP synthesis by guanylate cyclases, and… CONTINUE READING