Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway

@article{Almeida2004NitricOS,
  title={Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway},
  author={A. Almeida and S. Moncada and J. Bola{\~n}os},
  journal={Nature Cell Biology},
  year={2004},
  volume={6},
  pages={45-51}
}
  • A. Almeida, S. Moncada, J. Bolaños
  • Published 2004
  • Biology, Medicine
  • Nature Cell Biology
  • After inhibition of cytochrome c oxidase by nitric oxide, astrocytes maintain energy production by upregulating glycolysis — a response which does not seem to be available to neurons. Here, we show that in astrocytes, after inhibition of respiration by nitric oxide, there is a rapid, cyclic GMP-independent increase in the activity of 6-phosphofructo-1-kinase (PFK1), a master regulator of glycolysis, and an increase in the concentration of its most powerful positive allosteric activator… CONTINUE READING

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