Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway

@article{Almeida2004NitricOS,
  title={Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway},
  author={Angeles Almeida and Salvador Moncada and Juan P Bola{\~n}os},
  journal={Nature Cell Biology},
  year={2004},
  volume={6},
  pages={45-51}
}
After inhibition of cytochrome c oxidase by nitric oxide, astrocytes maintain energy production by upregulating glycolysis — a response which does not seem to be available to neurons. Here, we show that in astrocytes, after inhibition of respiration by nitric oxide, there is a rapid, cyclic GMP-independent increase in the activity of 6-phosphofructo-1-kinase (PFK1), a master regulator of glycolysis, and an increase in the concentration of its most powerful positive allosteric activator… CONTINUE READING
Highly Influential
This paper has highly influenced 14 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
148 Citations
30 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 148 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 30 references

( PFKFB 3 ) : promoter characterization and genomic structure

  • S. Ambrosio, F. Ventura, J. L. Rosa, R. Bartons
  • 2001

maker and breaker of the essential biofactor fructose-2,6-bisphosphate

  • Okar, D. A. et al. PFK-2FBPase-2
  • Trends Biochem. Sci. 26, 30–35
  • 2001

promoter characterization and genomic structure

  • Navarro-Sabate, A. et al. The human ubiquitous 6-phosphofructo-2-kinasefructose2, 6-bisphosphatase gene PFKFB3
  • Gene 264, 131–138
  • 2001

Similar Papers

Loading similar papers…