Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock

Abstract

Inflammasomes are multi-protein complexes that trigger the activation of caspase-1 and the maturation of interleukin-1β (IL-1β), yet the regulation of these complexes remains poorly characterized. Here we show that nitric oxide (NO) inhibited the NLRP3-mediated ASC pyroptosome formation, caspase-1 activation and IL-1β secretion in myeloid cells from both… (More)
DOI: 10.1038/cr.2013.6

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