Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock

@inproceedings{Mao2013NitricOS,
  title={Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock},
  author={Kairui Mao and Shuzhen Chen and Mingkuan Chen and Yonglei Ma and Yan Xiu Wang and Bo Huang and Zhengyu He and Yan Zeng and Yu Hu and Shuhui Sun and Jing Li and Xiaodong Wu and Xiangrui Wang and Warren Strober and Chang Chen and Guangxun Meng and Bing Sun},
  booktitle={Cell Research},
  year={2013}
}
Inflammasomes are multi-protein complexes that trigger the activation of caspase-1 and the maturation of interleukin-1β (IL-1β), yet the regulation of these complexes remains poorly characterized. Here we show that nitric oxide (NO) inhibited the NLRP3-mediated ASC pyroptosome formation, caspase-1 activation and IL-1β secretion in myeloid cells from both mice and humans. Meanwhile, endogenous NO derived from iNOS (inducible form of NO synthase) also negatively regulated NLRP3 inflammasome… CONTINUE READING

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