Nitric oxide stimulates cGMP formation in rat optic nerve axons, providing a specific marker of axon viability.

@article{Garthwaite1999NitricOS,
  title={Nitric oxide stimulates cGMP formation in rat optic nerve axons, providing a specific marker of axon viability.},
  author={Giti Garthwaite and David A. Goodwin and John Garthwaite},
  journal={The European journal of neuroscience},
  year={1999},
  volume={11 12},
  pages={4367-72}
}
A major transduction pathway for nitric oxide (NO) is stimulation of soluble guanylyl cyclase and the generation of cyclic GMP (cGMP). In the central nervous system, the NO-cGMP pathway has previously been associated primarily with synapses, particularly glutamatergic synapses. We report here that NO caused a large increase in the levels of cGMP in a central white matter tract devoid of synapses, namely in the rat isolated optic nerve. Cyclic GMP immunohistochemistry indicated that this… CONTINUE READING
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