Nitric oxide-stimulated guanine nucleotide exchange on p21ras.

  title={Nitric oxide-stimulated guanine nucleotide exchange on p21ras.},
  author={Harry M. Lander and Jason S Ogiste and S. Frieda A. Pearce and Roberto Levi and Abraham Novogrodsky},
  journal={The Journal of biological chemistry},
  volume={270 13},
The protooncogene p21ras, a monomeric G protein family member, plays a critical role in converting extracellular signals into intracellular biochemical events. Here, we report that nitric oxide (NO) activates p21ras in human T cells as evidenced by an increase in GTP-bound p21ras. In vitro studies using pure recombinant p21ras demonstrate that the activation is direct and reversible. Circular dichroism analysis reveals that NO induces a profound conformational change in p21ras in association… CONTINUE READING

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