Nitric oxide signaling pathway activation inhibits the immune escape of pancreatic carcinoma cells

@inproceedings{Lu2014NitricOS,
  title={Nitric oxide signaling pathway activation inhibits the immune escape of pancreatic carcinoma cells},
  author={Yebin Lu and Juanjuan Hu and Weijia Sun and Xiaohui Duan and Xiong Chen},
  booktitle={Oncology letters},
  year={2014}
}
The aim of the present study was to investigate the effect of the nitric oxide signaling pathway on immune escape; thus, a tumorigenesis model was established using nude mice. The mice were inoculated with pancreatic carcinoma cells and divided into two groups, a glyceryl trinitrate (GTN) and a placebo group. When tumor volumes reached 150 mm3, the mice in the GTN group were treated with GTN transdermal patches (dose, 7.3 μg/h) while the mice in the placebo group were administered untreated… CONTINUE READING
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