Nitric oxide short-circuits interleukin-12-mediated tumor regression

  title={Nitric oxide short-circuits interleukin-12-mediated tumor regression},
  author={Nejat K. Egilmez and Jamie Lynn Harden and Lauren P. Virtuoso and Reto Albert Schwendener and Mehmet Okyay Kilinc},
  journal={Cancer Immunology, Immunotherapy},
Interleukin-12 (IL-12) can promote tumor regression via activation of multiple lymphocytic and myelocytic effectors. Whereas the cytotoxic mechanisms employed by T/NK/NKT cells in IL-12-mediated tumor kill are well defined, the antitumor role of macrophage-produced cytotoxic metabolites has been more controversial. To this end, we investigated the specific role of nitric oxide (NO), a major macrophage effector molecule, in post-IL-12 tumor regression. Analysis of tumors following a single… CONTINUE READING


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A (2007) Interleukin-12: biological properties and clinical application

  • M Del Vecchio, E Bajetta, +4 authors Anichini
  • Clin Cancer Res
  • 2007
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