Nitric oxide selectively suppresses IH currents mediated by HCN1-containing channels.

@article{KoppScheinpflug2015NitricOS,
  title={Nitric oxide selectively suppresses IH currents mediated by HCN1-containing channels.},
  author={Cornelia Kopp-Scheinpflug and Beatrice M. Pigott and Ian D. Forsythe},
  journal={The Journal of physiology},
  year={2015},
  volume={593 7},
  pages={1685-700}
}
Hyperpolarization-activated non-specific cation-permeable channels (HCN) mediate I(H) currents, which are modulated by cGMP and cAMP and by nitric oxide (NO) signalling. Channel properties depend upon subunit composition (HCN1-4 and accessory subunits) as demonstrated in expression systems, but physiological relevance requires investigation in native neurons with intact intracellular signalling. Here we use the superior olivary complex (SOC), which exhibits a distinctive pattern of HCN1 and… CONTINUE READING