Nitric oxide scavengers in the treatment of shock associated with systemic inflammatory response syndrome.

@article{Angelo1999NitricOS,
  title={Nitric oxide scavengers in the treatment of shock associated with systemic inflammatory response syndrome.},
  author={J De Angelo},
  journal={Expert opinion on pharmacotherapy},
  year={1999},
  volume={1 1},
  pages={19-29}
}
  • J De Angelo
  • Published 1999 in Expert opinion on pharmacotherapy
Shock associated with systemic inflammatory response syndrome (SIRS) is a form of distributive shock affecting over 200,000 patients per year in the US that results in 50% mortality. The role of NO in a variety of shock states has been extensively studied and has been shown to be the primary effector in endotoxin lipopolysaccharide (LPS)-induced hypotension attendant to shock associated with sepsis or presumed sepsis. NO has also been shown to be a myocardial depressant, an inhibitor of… CONTINUE READING

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