Nitric oxide reverts the resistance to doxorubicin in human colon cancer cells by inhibiting the drug efflux.

@article{Riganti2005NitricOR,
  title={Nitric oxide reverts the resistance to doxorubicin in human colon cancer cells by inhibiting the drug efflux.},
  author={Chiara Riganti and Erica Miraglia and Daniele Viarisio and C Alejandra Costamagna and Gianpiero Pescarmona and Dario Ghigo and Amalia Bos{\`i}a},
  journal={Cancer research},
  year={2005},
  volume={65 2},
  pages={
          516-25
        }
}
Multidrug resistance (MDR) is a phenomenon by which cancer cells evade the cytotoxic effects of chemotherapeutic agents. It may occur through different mechanisms, but it often correlates with the overexpression of integral membrane transporters, such as P-glycoprotein (Pgp) and MDR-associated proteins (MRPs), with resulting decrease of drug accumulation and cellular death. Doxorubicin is a substrate of Pgp; it has been suggested that its ability to induce synthesis of nitric oxide (NO) could… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 51 REFERENCES

Nitric oxide contributes to adriamycin's antitumor effect.

  • The Journal of surgical research
  • 1997
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Peroxynitrite induces tyrosine nitration and tyrosine phosphorylation of synaptic proteins

AM Di Stasi, C Mallozzi, G Macchia, TC Petrucci, M. Minetti
  • J Neurochem 1999;73:727–35
  • 2005
VIEW 1 EXCERPT

nitrosylation in health and disease

MW Foster, TJ McMahon, JS SStamler
  • Trends Mol Med
  • 2003
VIEW 2 EXCERPTS

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