Nitric oxide release during alpha1-adrenoceptor-mediated constriction of arterioles.

  title={Nitric oxide release during alpha1-adrenoceptor-mediated constriction of arterioles.},
  author={Jay L Tuttle and Jeff C. Falcone},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={281 2},
We examined endothelial modulation of norepinephrine (NE)-mediated constriction in isolated, cannulated, first-order arterioles from skeletal muscle of rats. Acute arteriolar constrictor responses to NE (10(-9) to 10(-7) M) were significantly (P < 0.05) enhanced after either endothelial denudation or inhibition of nitric oxide synthase with NG-monomethyl-L-arginine (10(-4) M, 30 min). In contrast, arteriolar constrictions to NE were not different after treatment with either the cyclooxygenase… CONTINUE READING
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