Nitric oxide release combined with nonsteroidal antiinflammatory activity prevents muscular dystrophy pathology and enhances stem cell therapy.

@article{Brunelli2007NitricOR,
  title={Nitric oxide release combined with nonsteroidal antiinflammatory activity prevents muscular dystrophy pathology and enhances stem cell therapy.},
  author={Silvia Brunelli and Clara Sciorati and Giuseppe D'Antona and Anna Innocenzi and Diego Covarello and Beatriz G G{\'a}lvez and Cristiana Perrotta and Angela Monopoli and Francesca Sanvito and Roberto Bottinelli and Ennio Ongini and Giulio Cossu and Emilio Clementi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 1},
  pages={264-9}
}
Duchenne muscular dystrophy is a relatively common disease that affects skeletal muscle, leading to progressive paralysis and death. There is currently no resolutive therapy. We have developed a treatment in which we combined the effects of nitric oxide with nonsteroidal antiinflammatory activity by using HCT 1026, a nitric oxide-releasing derivative of flurbiprofen. Here, we report the results of long-term (1-year) oral treatment with HCT 1026 of two murine models for limb girdle and Duchenne… CONTINUE READING