Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

@article{Palmer1987NitricOR,
  title={Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor},
  author={R. Palmer and A. Ferrige and S. Moncada},
  journal={Nature},
  year={1987},
  volume={327},
  pages={524-526}
}
Endothelium-derived relaxing factor (EDRF) is a labile humoral agent which mediates the action of some vasodilators. Nitrovasodi-lators, which may act by releasing nitric oxide (NO), mimic the effect of EDRF and it has recently been suggested by Furchgott1 that EDRF may be NO. We have examined this suggestion by studying the release of EDRF and NO from endothelial cells in culture. NO was determined as the chemiluminescent product of its reaction with ozone2. The biological activity of EDRF and… Expand
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