Nitric oxide regulation of tissue free radical injury.

  title={Nitric oxide regulation of tissue free radical injury.},
  author={Homero Rubbo and Victor M. Darley-Usmar and Bruce A. Freeman},
  journal={Chemical research in toxicology},
  volume={9 5},
We have presented evidence from a broad range of chemical, cell biological, and in vivo studies showing that .NO can mediate tissue-protective reactions during oxidant stress, as well as toxic and tissue prooxidant effects. One predominant factor that has been identified which influences .NO being protective versus toxic is the relative rates of production and concentrations of .NO and the more "traditional" family of reactive oxygen species, including O2.-, H2O2, .OH, LO., LOO., and high… CONTINUE READING

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