Nitric oxide regulation of microvascular oxygen exchange during hypoxia and hyperoxia.

@article{Cabrales2006NitricOR,
  title={Nitric oxide regulation of microvascular oxygen exchange during hypoxia and hyperoxia.},
  author={Pedro J. Cabrales and Amy G. Tsai and Marcos Intaglietta},
  journal={Journal of applied physiology},
  year={2006},
  volume={100 4},
  pages={
          1181-7
        }
}
The objective of this work was to test the hypothesis that the limitation of nitric oxide (NO) availability accentuates microvascular reactivity to oxygen. The awake hamster chamber window model was rendered hypoxic and hyperoxic by ventilation with 10 and 100% oxygen. Systemic and microvascular parameters were determined in the two conditions and compared with normoxia in a group receiving the NO scavenger nitronyl nitroxide and a control group receiving only the vehicle (saline). Mean… 
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